Translational Multimodal Bioelectronics: From Biosymbiotic Devices to Clinically Integrated Digital Health

Abstract: Advances in soft materials, low-power circuits, and wireless energy harvesting now allow imperceptible, long-lived bioelectronic systems that are practical beyond the lab bench. This talk presents translational pathways for multimodal bioelectronics that bridge engineering innovation with clinical impact. We highlight epidermal and implantable platforms that acquire high-fidelity biosignals—EEG/IMU for neonatal seizure risk and sleep, ECG–SCG–PCG for cardiopulmonary coordination, and oral ISFET-based pH sensors for chemo- physiological context—and describe the materials, packaging, and system architectures that enable stable, week-scale wear. Beyond device physics, we emphasize translation: firmware that guarantees sub-10 ms synchronization across channels, analytics pipelines that integrate signal quality indices with explainable ML models, and HIPAA-compliant clinician dashboards that transform continuous raw streams into actionable insights. Case studies from NICU deployments and adult cohorts illustrate how biosymbiotic devices can support seizure detection, brain–heart dysregulation screening, and personalized therapy planning. By uniting materials, systems, and AI with real clinical use, these efforts outline a roadmap for multimodal digital healthcare that is both technically rigorous and translatable to patient care.
References: PNAS June 2025 122 (23) e2501220122; Nature Medicine (under review); Nature BME (under submission)
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Speaker(s): Assist. Prof. Yayun Du
Agenda:
6:50 – 7 PM: Registration
7-8 PM: Talk and Q&A
Virtual: https://events.vtools.ieee.org/m/515108